{"id":3605,"date":"2025-11-03T15:00:32","date_gmt":"2025-11-03T15:00:32","guid":{"rendered":"https:\/\/bangbizarre.com\/index.php\/2025\/11\/03\/alzheimers-disease-may-be-powered-by-disrupted-sleep-cycle-study-suggests\/"},"modified":"2025-11-03T15:00:34","modified_gmt":"2025-11-03T15:00:34","slug":"alzheimers-disease-may-be-powered-by-disrupted-sleep-cycle-study-suggests","status":"publish","type":"post","link":"https:\/\/bangbizarre.com\/index.php\/2025\/11\/03\/alzheimers-disease-may-be-powered-by-disrupted-sleep-cycle-study-suggests\/","title":{"rendered":"Alzheimer\u2019s disease may be powered by disrupted sleep cycle, study suggests"},"content":{"rendered":"<p><b>2025-11-03 15:00:31<\/b><br \/>\n<BR>Disrupted sleep may exacerbate Alzheimer\u2019s disease.<BR><br \/>\nScientists at Washington University School of Medicine in St. Louis have found that Alzheimer\u2019s interferes with the brain\u2019s circadian rhythms, the internal clock that regulates sleep, wakefulness, and countless biological functions. <BR><br \/>\nThe study, published in Nature Neuroscience, revealed that this disruption changes how hundreds of genes switch on and off throughout the day, affecting how the brain clears toxins and maintains its health.<BR><br \/>\n Professor Erik S. Musiek, the study\u2019s senior author, said: \u201cThere are 82 genes associated with Alzheimer\u2019s risk, and the circadian rhythm controls about half of those.<BR><br \/>\n\u201cWhen that rhythm breaks down, it changes the activity of these genes &#8211; and that could influence how the disease progresses.\u201d<BR><br \/>\nIn mouse models, researchers found that the build-up of amyloid &#8211; a sticky protein linked to Alzheimer\u2019s &#8211; threw the brain\u2019s internal timing into chaos. <BR><br \/>\nThe disturbance affected microglia and astrocytes, key cells that help clean up waste and support communication between neurons. <BR><br \/>\nWhen their daily rhythm faltered, so did their ability to remove harmful material like amyloid.<BR><br \/>\nThe team also discovered that Alzheimer\u2019s created new, irregular gene activity patterns in brain regions linked to inflammation and stress, further accelerating damage.<BR><br \/>\nProfessor Musiek said these findings could lead to new therapies that stabilise the body\u2019s biological clock to slow or even prevent Alzheimer\u2019s progression. <BR><br \/>\nHe said: \u201cWe hope to learn how to optimise the circadian system &#8211; to make it stronger or weaker in the right places &#8211; and use that to combat the disease.\u201d<BR><br \/>\nThe researchers believe improving sleep and maintaining consistent daily rhythms could one day form part of a new strategy to protect the brain from Alzheimer\u2019s.<br \/>\n<br \/><a href=\"https:\/\/bangbizarre.com\/\" target=\"_blank\"> Visit Bang Bizarre (main website) <\/a><br \/>\n<br \/><script src=\"https:\/\/geo.dailymotion.com\/player\/xtbac.js\" data-video=\"\"><\/script><\/p>\n","protected":false},"excerpt":{"rendered":"<p>2025-11-03 15:00:31 Disrupted sleep may exacerbate Alzheimer\u2019s disease. Scientists at Washington University School of Medicine in St. Louis have found that Alzheimer\u2019s interferes with the brain\u2019s circadian rhythms, the internal&hellip;<\/p>\n","protected":false},"author":1,"featured_media":2876,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[4],"tags":[],"class_list":["post-3605","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-bizarre"],"_links":{"self":[{"href":"https:\/\/bangbizarre.com\/index.php\/wp-json\/wp\/v2\/posts\/3605","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/bangbizarre.com\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/bangbizarre.com\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/bangbizarre.com\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/bangbizarre.com\/index.php\/wp-json\/wp\/v2\/comments?post=3605"}],"version-history":[{"count":1,"href":"https:\/\/bangbizarre.com\/index.php\/wp-json\/wp\/v2\/posts\/3605\/revisions"}],"predecessor-version":[{"id":3606,"href":"https:\/\/bangbizarre.com\/index.php\/wp-json\/wp\/v2\/posts\/3605\/revisions\/3606"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/bangbizarre.com\/index.php\/wp-json\/wp\/v2\/media\/2876"}],"wp:attachment":[{"href":"https:\/\/bangbizarre.com\/index.php\/wp-json\/wp\/v2\/media?parent=3605"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/bangbizarre.com\/index.php\/wp-json\/wp\/v2\/categories?post=3605"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/bangbizarre.com\/index.php\/wp-json\/wp\/v2\/tags?post=3605"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}