{"id":4362,"date":"2026-04-15T13:49:39","date_gmt":"2026-04-15T13:49:39","guid":{"rendered":"https:\/\/bangbizarre.com\/index.php\/2026\/04\/15\/women-battling-osteoporosis-may-carry-alzheimers-linked-gene\/"},"modified":"2026-04-15T13:49:40","modified_gmt":"2026-04-15T13:49:40","slug":"women-battling-osteoporosis-may-carry-alzheimers-linked-gene","status":"publish","type":"post","link":"https:\/\/bangbizarre.com\/index.php\/2026\/04\/15\/women-battling-osteoporosis-may-carry-alzheimers-linked-gene\/","title":{"rendered":"Women battling osteoporosis may carry Alzheimer&#039;s-linked gene"},"content":{"rendered":"<p><b>2026-04-15 13:49:38<\/b><br \/>\n<BR>Women diagnosed with osteoporosis could be carrying a hidden risk tied to Alzheimer\u2019s disease.<BR><br \/>\nScientists have discovered that APOE4 \u2013 the most common genetic risk factor for Alzheimer\u2019s \u2013 may quietly weaken bones in women, even when routine scans suggest everything is normal. <BR><br \/>\nThe study, led by researchers at the Buck Institute for Research on Ageing in California, US and UC San Francisco, found that this gene can damage bone at a microscopic level before any visible warning signs appear. <BR><br \/>\nThese subtle changes can begin as early as midlife, slipping under the radar of standard imaging tests used to assess bone density.<BR><br \/>\nExperts have long noticed a puzzling overlap: people with Alzheimer\u2019s tend to suffer more fractures, while osteoporosis in women has been flagged as an early predictor of cognitive decline.<BR><br \/>\nBy analysing proteins in aged mouse bone, researchers uncovered unusually high levels of molecules linked to neurological diseases, such as those linked to Alzheimer&#8217;s.<BR><br \/>\nBone cells, named osteocytes, showed a striking increase in APOE levels \u2013 especially in older female mice, where levels were double those seen in younger or male animals.<BR><br \/>\nFurther experiments revealed that APOE4 disrupts a crucial maintenance process inside bone cells. <BR><br \/>\nThis prevents them from repairing tiny internal channels that help keep bones strong and flexible.<BR><br \/>\nBones become more fragile despite appearing perfectly healthy on scans.<BR><br \/>\nResearchers say this invisible damage is what makes the discovery so significant. Bone may be deteriorating in ways doctors simply cannot detect with current tools.<BR><br \/>\nIntriguingly, in other experiments using geneticlaly modified mice, the impact of APOE4 was even greater in bone than in brain tissue.<br \/>\n<br \/><a href=\"https:\/\/bangbizarre.com\/\" target=\"_blank\"> Visit Bang Bizarre (main website) <\/a><br \/>\n<br \/><script src=\"https:\/\/geo.dailymotion.com\/player\/xtbac.js\" data-video=\"\"><\/script><\/p>\n","protected":false},"excerpt":{"rendered":"<p>2026-04-15 13:49:38 Women diagnosed with osteoporosis could be carrying a hidden risk tied to Alzheimer\u2019s disease. Scientists have discovered that APOE4 \u2013 the most common genetic risk factor for Alzheimer\u2019s&hellip;<\/p>\n","protected":false},"author":1,"featured_media":2133,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[4],"tags":[],"class_list":["post-4362","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-bizarre"],"_links":{"self":[{"href":"https:\/\/bangbizarre.com\/index.php\/wp-json\/wp\/v2\/posts\/4362","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/bangbizarre.com\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/bangbizarre.com\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/bangbizarre.com\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/bangbizarre.com\/index.php\/wp-json\/wp\/v2\/comments?post=4362"}],"version-history":[{"count":1,"href":"https:\/\/bangbizarre.com\/index.php\/wp-json\/wp\/v2\/posts\/4362\/revisions"}],"predecessor-version":[{"id":4363,"href":"https:\/\/bangbizarre.com\/index.php\/wp-json\/wp\/v2\/posts\/4362\/revisions\/4363"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/bangbizarre.com\/index.php\/wp-json\/wp\/v2\/media\/2133"}],"wp:attachment":[{"href":"https:\/\/bangbizarre.com\/index.php\/wp-json\/wp\/v2\/media?parent=4362"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/bangbizarre.com\/index.php\/wp-json\/wp\/v2\/categories?post=4362"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/bangbizarre.com\/index.php\/wp-json\/wp\/v2\/tags?post=4362"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}