2026-04-08 13:15:00

A diabetes pill may mimic the effects of intense exercise.

Researches believe that metformin – a common National Health Service (NHS) prescription used to treat type 2 diabetes – could trigger similar metabolic benefits to a tough workout.

In a new study, scientists discovered the pill boosts levels of a molecule linked to physical activity, raising hopes it could help control weight and protect heart health.

Experts from the University of Miami Miller School of Medicine examined 29 men with prostate cancer and found metformin increased levels of N-lactoyl-phenylalanine – or Lac-Phe – a compound typically released after intense exercise.

Lac-Phe has been associated with appetite suppression and weight loss, making it a key target for scientists exploring new ways to tackle obesity and metabolic disease.

Lead researcher Dr Marijo Bilusic said: “From a clinical standpoint, seeing a metabolic signal that mirrors what we associate with intense exercise was striking.

“For patients whose treatments or symptoms limit physical activity, that kind of effect could be especially meaningful.”

While the drug did not directly treat prostate cancer, researchers say the metabolic boost alone could improve patients’ overall health – particularly those too fatigued to stay active.

Professor David Lombard added: “These findings suggest Lac-Phe may be a very informative signal for understanding how metformin affects metabolism.”

The team stressed the discovery is not a cure — but it could pave the way for new treatments that support the body during illness.

Dr Bilusic said the findings offer “a clearer understanding of how a widely used drug may support metabolic health”.

Metformin has already been linked to a reduced risk of certain cancers and is also prescribed for conditions like polycystic ovary syndrome.

Researchers say more studies are needed.

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